Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2805304 | 0.78 | REN (0.44) | NR1H4RENGAATSHRALDH1A1 | |
| SCHEMBL1072359 | 0.74 | SLC6A4 (0.42) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL662474 | 0.72 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3CYP2D6NR1H4 | |
| SCHEMBL18509018 | 0.71 | REN (0.43) | NR1H4RENGAATSHRALDH1A1 | |
| SCHEMBL662475 | 0.70 | REN (0.44) | NR1H4RENHTR2A | |
| SCHEMBL2811860 | 0.69 | REN (0.45) | SLC6A2SLC6A4SLC6A3NR1H4REN | |
| SCHEMBL661553 | 0.69 | REN (0.38) | SLC6A2SLC6A4SLC6A3CYP2D6NR1H4 | |
| SCHEMBL14036780 | 0.69 | KDM4E (0.36) | ADRA1DADRA1AADRA1BCYP1A2ADRA2A | |
| SCHEMBL1518385 | 0.69 | REN (0.47) | REN | |
| SCHEMBL13132250 | 0.69 | REN (0.43) | NR1H4REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |