Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.34 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14010667 | 0.83 | PDK2 (0.48) | PDK2KIF11PTPN1HTR2AHTR2C | |
| Trifluoroacetic Acid SCHEMBL5005103 | 0.81 | PDK2 (0.46) | PDK2KIF11PTPN1HTR2AHTR2C | |
| SCHEMBL5005104 | 0.68 | LMNA (0.37) | PDK2KMT2AERCC1ERCC4 | |
| SCHEMBL18779301 | 0.64 | HDAC1 (0.57) | PDK2KIF11HDAC1KMT2A | |
| SCHEMBL27393194 | 0.64 | MAPK14 (0.52) | PDK2HDAC1KMT2ANPC1POLB | |
| SCHEMBL16250732 | 0.63 | MAPK14 (0.54) | PDK2HDAC1KMT2ANPC1POLB | |
| SCHEMBL97001 | 0.61 | KMT2A (0.68) | PTPN1HDAC1KMT2APOLBRAB9A | |
| SCHEMBL7366509 | 0.60 | KMT2A (0.53) | PDK2KIF11HDAC1KMT2APOLB | |
| Cyclopropane SCHEMBL6695009 | 0.60 | KMT2A (0.61) | PTPN1HTR2AHTR2CHTR2BHDAC1 | |
| SCHEMBL8281923 | 0.60 | KMT2A (0.49) | PDK2KIF11HDAC1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293709-A1 | Novel 2-Amino-Heterocycles Useful in the Treatment of Abeta-Related Pathologies | ASTRAZENECA AB (SE) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293709-A1 | Novel 2-Amino-Heterocycles Useful in the Treatment of Abeta-Related Pathologies | PSEN2, APP, PSEN1 | PDK2 2218/4885KIF11 4801/4885PTPN1 4832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.