Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 10/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.42 |
| ▸ | UBE2M | P61081 | 6/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 6/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14036787 | 0.82 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14036693 | 0.81 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14036807 | 0.78 | PSEN1 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14036790 | 0.77 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14036573 | 0.75 | TP53 (0.41) | UBE2MDCUN1D1TP53MAPT | |
| SCHEMBL14036793 | 0.75 | UBE2M (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14036794 | 0.74 | PSEN1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14036683 | 0.74 | PSEN1 (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14036635 | 0.73 | TP53 (0.39) | UBE2MDCUN1D1TP53MAPT | |
| SCHEMBL14036554 | 0.72 | USP30 (0.44) | UBE2MDCUN1D1USP30TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008137102-A2 | METHODS OF MODULATING AMYLOID BETA AND COMPOUNDS USEFUL THEREFOR | TORREYPINES THERAPEUTICS, INC. (US) | 2008-11-13 | — | — | WO | disclosed |