Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 6/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | TRIM58 | Q8NG06 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3329768 | 0.75 | BRD4 (0.38) | JAK2JAK1JAK3EP300CHRM1 | |
| SCHEMBL14037940 | 0.74 | PDE10A (0.46) | — | |
| SCHEMBL3330960 | 0.72 | PIM1 (0.51) | JAK2JAK1JAK3CHRM1CHRM2 | |
| SCHEMBL4555954 | 0.66 | SYK (0.46) | BRD4ATAD2 | |
| SCHEMBL4555662 | 0.64 | VCP (0.38) | — | |
| SCHEMBL3331131 | 0.63 | PIM1 (0.48) | BRD4ATAD2 | |
| SCHEMBL11915765 | 0.62 | PIM1 (0.47) | — | |
| SCHEMBL3331234 | 0.62 | PIM1 (0.50) | — | |
| Hydrochloric Acid SCHEMBL6582848 | 0.57 | BRD4 (0.50) | KHKBRD4ATAD2 | |
| SCHEMBL5605238 | 0.56 | PRMT5 (0.45) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008133955-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | EXELIXIS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |