Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.40 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1450235 | 0.88 | GPR119 (0.43) | TP53GPR119HCAR1RECQLSRC | |
| SCHEMBL14038347 | 0.86 | GPR119 (0.38) | GPR119FAAH | |
| SCHEMBL1450149 | 0.82 | GPR119 (0.44) | TP53GPR119HCAR1RECQLSRC | |
| SCHEMBL10269111 | 0.81 | GPR119 (0.46) | GPR119 | |
| SCHEMBL4572397 | 0.80 | CYP3A4 (0.42) | TP53GPR119CYP3A4 | |
| SCHEMBL12546186 | 0.80 | GPR119 (0.53) | GPR119 | |
| SCHEMBL11913111 | 0.80 | CYP3A4 (0.37) | TP53GPR119CYP3A4 | |
| SCHEMBL11913109 | 0.78 | CYP2C9 (0.41) | GPR119CYP3A4 | |
| SCHEMBL11913107 | 0.78 | GPR119 (0.46) | GPR119SRCEGFRCYP3A4 | |
| SCHEMBL14038352 | 0.78 | RECQL (0.40) | TP53GPR119RECQLHPGDFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008137435-A1 | [6,6] AND [6,7]-BICYCLIC GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-11-13 | — | — | WO | disclosed |