Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.31 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13287382 | 0.90 | RAB9A (0.37) | GPR139RAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL13287465 | 0.86 | RAB9A (0.33) | GPR139RAB9ANPC1TP53SMN1; SMN2 | |
| SCHEMBL13287388 | 0.80 | MAPK1 (0.37) | RAB9ANPC1TP53SMN1; SMN2GAA | |
| SCHEMBL13292033 | 0.78 | FFAR2 (0.30) | FFAR2 | |
| SCHEMBL2827321 | 0.78 | MPL (0.33) | RAB9ANPC1SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL13287443 | 0.77 | MPL (0.31) | GAAFFAR2MEN1KMT2A | |
| SCHEMBL13287357 | 0.77 | FFAR2 (0.30) | FFAR2 | |
| SCHEMBL2827653 | 0.77 | MPL (0.32) | SMN1; SMN2FFAR2 | |
| SCHEMBL2827672 | 0.77 | NPC1 (0.32) | RAB9ANPC1GAAALDH1A1HPGD | |
| SCHEMBL2827674 | 0.77 | NPC1 (0.32) | RAB9ANPC1GAAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318928-B2 | Fused imidazole carboxamides as TRPV3 modulators | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2012-11-27 | — | — | US | disclosed |