Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.31 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.31 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14040646 | 0.94 | MC4R (0.42) | MC4RKMT2AALDH1A1HTTNPSR1 | |
| SCHEMBL25226033 | 0.80 | KDM4E (0.34) | KMT2AKDM4EALDH1A1LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL25222133 | 0.79 | KDM4E (0.33) | KMT2AKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL13281154 | 0.74 | GABRA5 (0.35) | KMT2AKDM4E | |
| SCHEMBL7921878 | 0.71 | EPHX1 (0.44) | KMT2AKDM4EALDH1A1MITFSMN1; SMN2 | |
| SCHEMBL25229077 | 0.71 | ALDH1A1 (0.40) | KMT2AKDM4EALDH1A1HTTNPSR1 | |
| SCHEMBL378774 | 0.70 | POLB (0.47) | KMT2AALDH1A1HTTLMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL23539591 | 0.69 | ALDH1A1 (0.39) | KMT2AKDM4EALDH1A1HTTNPSR1 | |
| SCHEMBL18935464 | 0.69 | KDM4E (0.40) | KMT2AKDM4EALDH1A1HTTNPSR1 | |
| SCHEMBL7910450 | 0.69 | ATM (0.61) | MC4RKMT2AALDH1A1ATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411940-B1 | BRIDGED PIPERIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | MERCK & CO INC (US) | 2008-10-15 | — | — | EP | disclosed |