SCHEMBL14040679

SCHEMBL14040679

Cc1ccc(C2(c3ccc(O)cc3O)C3CC4CC(C3)CC2C4)c(O)c1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.36
ALOX5AP P20292 1/20 0.36
CNR2 P34972 2/20 0.36
HSD11B1 P28845 1/20 0.35
HSP90AA1 P07900 1/20 0.35
P2RX7 Q99572 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C19 P33261 1/20 0.33
LMNA P02545 1/20 0.32
CHRM1 P11229 1/20 0.32
SLC6A2 P23975 1/20 0.32
ADRA1A P35348 1/20 0.32
HTR2B P41595 1/20 0.32
ACHE P22303 2/20 0.32
TP53 P04637 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3756901 0.91 ALOX5AP (0.41) ALOX5APCNR2HSP90AA1TDP1
SCHEMBL14040564 0.78 CNR2 (0.43) TRPA1CNR2HSP90AA1
SCHEMBL3762657 0.77 ALOX5AP (0.51) ALOX5APHSP90AA1CYP1A2CYP2C19TP53
SCHEMBL11702433 0.72 CNR2 (0.51) TRPA1CNR2P2RX7TP53
SCHEMBL17370937 0.72 HSD11B1 (0.50) HSD11B1SLC6A2ACHE
SCHEMBL3757284 0.71 MEN1 (0.36) ALOX5AP
SCHEMBL3752236 0.70 ALOX5AP (0.35) ALOX5AP
SCHEMBL4606696 0.70 CNR2 (0.46) TRPA1CNR2HSD11B1P2RX7
SCHEMBL3132046 0.70 ALOX5AP (0.40) ALOX5APHSD11B1LMNATDP1
SCHEMBL2420330 0.68 MEN1 (0.50) CNR2HSP90AA1TP53TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1985616-A1 ADAMANTANE DERIVATIVE, RESIN COMPOSITION CONTAINING SAME, AND OPTOELECTRONIC MEMBER AND SEALING AGENT FOR ELECTRONIC CIRCUIT USING THOSE Idemitsu Kosan Co., Ltd. (JP) 2008-10-29 EP disclosed