Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 3/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.53 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.53 |
| ▸ | CLK2 | P49760 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.47 |
| ▸ | PRKCA | P17252 | 2/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | PRKCG | P05129 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6497264 | 0.81 | ABL1 (0.53) | MAPTPRKCAPRKCDPIK3CGPIK3CA | |
| SCHEMBL8253883 | 0.81 | ZAP70 (0.68) | PRKCAPRKCDPRKD3PRKCGPRKCB | |
| SCHEMBL12764230 | 0.81 | PRKCA (0.56) | CLK4DYRK1BMEN1KMT2APRKCA | |
| SCHEMBL14088787 | 0.78 | JAK2 (0.59) | DYRK1ACLK4MEN1KMT2APRKCA | |
| SCHEMBL6981394 | 0.75 | CLK1 (0.69) | CLK1DYRK1ACLK4DYRK1BCLK2 | |
| SCHEMBL22181808 | 0.73 | EPHB4 (0.51) | EPHB4EGFRAURKACDK2 | |
| SCHEMBL14253944 | 0.73 | IKBKB (0.61) | MEN1KMT2APRKCAPRKCDPRKD3 | |
| SCHEMBL27116600 | 0.72 | ABL1 (0.57) | MEN1MAPTKMT2APRKCAPRKCD | |
| SCHEMBL22181818 | 0.72 | EPHB4 (0.49) | MEN1KMT2ALMNAEPHB4EGFR | |
| SCHEMBL10977837 | 0.71 | PIK3CG (0.78) | MEN1ALDH1A1MAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373257-B9 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2008-10-15 | — | — | EP | disclosed |
| EP-1373257-B1 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-28 | — | — | EP | disclosed |