Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | BCR | P11274 | 2/20 | 0.53 |
| ▸ | PRKCA | P17252 | 1/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.53 |
| ▸ | CAMK2D | Q13557 | 6/20 | 0.52 |
| ▸ | CDK2 | P24941 | 3/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12764224 | 0.82 | ABL1 (0.62) | ABL1BCRPRKCAPRKCDCAMK2D | |
| SCHEMBL8254301 | 0.82 | PIK3CG (0.69) | ABL1BCRPRKCAPRKCDCAMK2D | |
| SCHEMBL14040916 | 0.81 | CLK1 (0.53) | ABL1PRKCAPRKCDCDK2SMG1 | |
| SCHEMBL4712159 | 0.76 | SMG1 (0.57) | ABL1BCRPRKCAPRKCDCAMK2D | |
| SCHEMBL12800918 | 0.76 | CAMK2D (0.67) | ABL1BCRPRKCAPRKCDCAMK2D | |
| SCHEMBL5733563 | 0.75 | MAPT (0.72) | ABL1BCRPRKCAPRKCDCAMK2D | |
| SCHEMBL27116597 | 0.75 | PIK3CG (0.73) | ABL1BCRPRKCAPRKCDCAMK2D | |
| SCHEMBL12275494 | 0.74 | PLK1 (0.70) | ABL1BCRPRKCAPRKCDCAMK2D | |
| SCHEMBL12274914 | 0.73 | CAMK2D (0.57) | ABL1BCRPRKCAPRKCDCAMK2D | |
| SCHEMBL3614861 | 0.73 | ABL1 (0.61) | ABL1BCRPRKCAPRKCDCAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6949544-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-09-27 | — | — | US | disclosed |
| US-20030087922-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087922-A1 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | CDK2, LCK, CDK5 | ABL1 255/4885BCR 1092/4885PRKCA 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.