Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4713381 | 0.90 | PLK1 (0.59) | MAPTLMNAPLK1ALDH1A1HPGD | |
| SCHEMBL4938172 | 0.78 | PLK1 (0.55) | PLK1ALDH1A1SMN1; SMN2CYP3A4KDM4E | |
| SCHEMBL4712109 | 0.78 | PLK1 (0.55) | MAPTLMNAPLK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1464754 | 0.76 | PLK1 (0.57) | MAPTPLK1ALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL4940987 | 0.76 | PLK1 (0.54) | MAPTPLK1ALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL805335 | 0.76 | MAPT (0.69) | MAPTLMNAALDH1A1HPGDPOLB | |
| SCHEMBL783240 | 0.76 | MAPT (0.69) | MAPTLMNAALDH1A1HPGDPOLB | |
| SCHEMBL6976595 | 0.75 | RAB9A (0.64) | MAPTLMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6976592 | 0.75 | RAB9A (0.64) | MAPTLMNAALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30051479 | 0.75 | RAB9A (0.64) | MAPTLMNAALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373257-B9 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2008-10-15 | — | — | EP | disclosed |
| EP-1373257-B1 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2007-11-28 | — | — | EP | disclosed |