Sugi Predict

Sugi Predict / Compounds / SCHEMBL1464754

SCHEMBL1464754

SCHEMBL1464754

COC(=O)c1cc(OC)c2c(c1)OCO2

nearest known ligand 0.57

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ PLK1 P53350 1/20 0.57
▸ ALDH1A1 P00352 2/20 0.50
▸ CYP3A4 P08684 2/20 0.50
▸ KMT2A Q03164 3/20 0.49
▸ MEN1 O00255 2/20 0.48
▸ NPC1 O15118 5/20 0.48
▸ RAB9A P51151 5/20 0.48
▸ SMN1; SMN2 Q16637 4/20 0.48
▸ CASP3 P42574 1/20 0.48
▸ SENP7 Q9BQF6 1/20 0.48
▸ MAPT P10636 2/20 0.46
▸ ESR1 P03372 1/20 0.46
▸ EDNRB P24530 1/20 0.45
▸ EDNRA P25101 1/20 0.45
▸ TP53 P04637 1/20 0.45
▸ PKM P14618 1/20 0.45
▸ AHR P35869 1/20 0.45
▸ TAS2R8 Q9NYW2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2796317 0.88 PLK1 (0.74) PLK1ALDH1A1KMT2AMEN1NPC1
SCHEMBL4938172 0.86 PLK1 (0.55) PLK1ALDH1A1CYP3A4KMT2AMEN1
SCHEMBL4712109 0.86 PLK1 (0.55) PLK1ALDH1A1CYP3A4KMT2AMEN1
SCHEMBL4940987 0.84 PLK1 (0.54) PLK1ALDH1A1CYP3A4KMT2AMEN1
SCHEMBL17714985 0.83 RAB9A (0.49) ALDH1A1CYP3A4KMT2AMEN1NPC1
SCHEMBL9512531 0.83 KDM4E (0.53) ALDH1A1CYP3A4KMT2AMEN1NPC1
SCHEMBL29901789 0.83 KDM4E (0.53) ALDH1A1CYP3A4KMT2AMEN1NPC1
SCHEMBL10608873 0.82 KMT2A (0.62) PLK1ALDH1A1CYP3A4KMT2AMEN1
SCHEMBL17715249 0.82 HPGD (0.46) PLK1ALDH1A1CYP3A4KMT2AMEN1
SCHEMBL5743163 0.82 CYP3A4 (0.55) PLK1ALDH1A1CYP3A4KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 271 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE50453-E1 Indole derivatives as CFTR modulators VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-06-10 — — US disclosed
US-20240092766-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMA (US) 2024-03-21 — — US disclosed
WO-2023158862-A2 STIMULATOR OF INTERFERON GENES (STING) MODULATORS, AND COMPOSITIONS AND METHODS THEREOF GEODE THERAPEUTICS INC. (US) 2023-08-24 — — WO disclosed
US-11661580-B2 Method of inhibiting tau phosphorylation CASSAVA SCIENCES, INC. (US) 2023-05-30 — — US disclosed
US-11639347-B2 Modulators of ATP-binding cassette transporters VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-05-02 — — US disclosed
US-11639347-B2 Modulators of ATP-binding cassette transporters VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-05-02 — — US disclosed
US-20230127655-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-04-27 — — US disclosed
US-20230127655-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-04-27 — — US disclosed
US-20230100634-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-03-30 — — US disclosed
US-20220411410-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED 2022-12-29 — — US disclosed
EP-0276051-B1 ANTINEOPLASTIC COMPOUNDS ARIZONA BOARD OF REGENTS (US) 1991-08-21 — — EP disclosed
US-5003091-A Preparation of 3-memory-4,5-methylenedioxybenzaldehyde RHONE-POULENC CHIMIE (FR) 1991-03-26 — — US disclosed
US-4996331-A Novel biphenyl derivative and preparation and use thereof TSUMURA & CO. (JP) 1991-02-26 — — US disclosed
US-4925872-A HEPATITIS TSUMURA & CO. (JP) 1990-05-15 — — US disclosed
EP-0219371-B1 ANISOLE DERIVATIVES MITSUBISHI KASEI CORPORATION (JP) 1989-11-08 — — EP disclosed
US-4849448-A LIVER DISORDER TREATMENT TSUMURA JUNTENDO, INC. (JP) 1989-07-18 — — US disclosed
EP-0276051-A2 Antineoplastic compounds ARIZONA BOARD OF REGENTS (US) 1988-07-27 — — EP disclosed
EP-0267970-A1 NOVEL BIPHENYL DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE TSUMURA & CO. (JP) 1988-05-25 — — EP disclosed
US-4746747-A Anisole derivatives MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) 1988-05-24 — — US disclosed
EP-0219371-A2 Anisole derivatives MITSUBISHI KASEI CORPORATION (JP) 1987-04-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220411410-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CFTR, ABCB1, ABCC2 PLK1 3956/4885ALDH1A1 1961/4885CYP3A4 1368/4885
US-20240092766-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CFTR, ABCB1, ABCC2 PLK1 3956/4885ALDH1A1 1961/4885CYP3A4 1368/4885
US-11661580-B2 Method of inhibiting tau phosphorylation FLNA, FLNB, MAPT PLK1 175/4885ALDH1A1 4388/4885CYP3A4 4699/4885
US-11639347-B2 Modulators of ATP-binding cassette transporters CFTR, ABCB1, ABCC2 PLK1 3956/4885ALDH1A1 1961/4885CYP3A4 1368/4885
US-20230100634-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CFTR, ABCB1, ABCC2 PLK1 3956/4885ALDH1A1 1961/4885CYP3A4 1368/4885
US-20230127655-A1 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS CFTR, ABCB1, ABCC2 PLK1 3956/4885ALDH1A1 1961/4885CYP3A4 1368/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.