Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | HRH2 | P25021 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14040973 | 0.90 | BLM (0.43) | BLMLMNAPMP22NPSR1HRH1 | |
| SCHEMBL9828176 | 0.89 | HRH1 (0.45) | BLMLMNAPMP22NPSR1HRH1 | |
| SCHEMBL8313063 | 0.88 | HRH1 (0.48) | BLMHRH1HRH3CHRM2CHRM5 | |
| SCHEMBL14040971 | 0.86 | HRH1 (0.44) | BLMLMNAPMP22NPSR1HRH1 | |
| SCHEMBL9710041 | 0.83 | NPY1R (0.54) | — | |
| SCHEMBL14040781 | 0.82 | SMN1; SMN2 (0.46) | BLMLMNAPMP22NPSR1HRH1 | |
| SCHEMBL9867526 | 0.82 | — | — | |
| SCHEMBL9827663 | 0.81 | ALDH1A1 (0.40) | CHRM2SLC6A2SLC6A4SCN1ASCN2A | |
| SCHEMBL9865155 | 0.80 | BLM (0.40) | BLMLMNAPMP22NPSR1HRH1 | |
| SCHEMBL14040972 | 0.79 | CHRM2 (0.45) | BLMLMNAPMP22NPSR1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318983-B1 | SUBSTITUTED IMIDAZOLES AS HISTAMINE H1 AND H3 AGONISTS OR ANTAGONISTS | SCHERING CORP (US) | 2008-10-22 | — | — | EP | disclosed |