Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | HRH2 | P25021 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14040781 | 0.89 | SMN1; SMN2 (0.46) | CHRM2CHRM5CHRM1ADRA2BSLC6A2 | |
| SCHEMBL14040971 | 0.86 | HRH1 (0.44) | CHRM2CHRM5CHRM1ADRA2BSLC6A2 | |
| SCHEMBL9828176 | 0.83 | HRH1 (0.45) | CHRM2CHRM5CHRM1ADRA2BSLC6A2 | |
| SCHEMBL14040973 | 0.82 | BLM (0.43) | CHRM2CHRM5CHRM1ADRA2BSLC6A2 | |
| SCHEMBL14040975 | 0.79 | BLM (0.46) | CHRM2CHRM5CHRM1ADRA2BSLC6A2 | |
| SCHEMBL8313063 | 0.78 | HRH1 (0.48) | CHRM2CHRM5CHRM1ADRA2BSLC6A2 | |
| SCHEMBL14040788 | 0.77 | LMNA (0.53) | CHRM2CHRM5CHRM1ADRA2BSLC6A2 | |
| SCHEMBL9710041 | 0.76 | NPY1R (0.54) | — | |
| SCHEMBL14040970 | 0.75 | LMNA (0.51) | CHRM2CHRM5CHRM1ADRA2BSLC6A2 | |
| SCHEMBL9827663 | 0.75 | ALDH1A1 (0.40) | CHRM2SLC6A2SLC6A4SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1318983-B1 | SUBSTITUTED IMIDAZOLES AS HISTAMINE H1 AND H3 AGONISTS OR ANTAGONISTS | SCHERING CORP (US) | 2008-10-22 | — | — | EP | disclosed |