Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21212754 | 0.83 | HSP90AA1 (0.41) | KDM4EALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL12953988 | 0.81 | CDK2 (0.38) | CDK2KDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL7545686 | 0.78 | KDM4E (0.57) | CDK2KDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL19436706 | 0.77 | KDM4E (0.66) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL11605893 | 0.75 | LMNA (0.46) | CDK2KDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL14050842 | 0.75 | GSK3B (0.42) | CDK2KDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL6515244 | 0.73 | KDM4E (0.43) | KDM4EALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL14043374 | 0.72 | GSK3B (0.50) | CDK2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19436668 | 0.71 | KDM4E (0.61) | KDM4EALDH1A1LMNAMAPTHSD17B10 | |
| SCHEMBL14050972 | 0.70 | GSK3B (0.40) | CDK2KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |