Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | IDO1 | P14902 | 5/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MIF | P14174 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NOS3 | P29474 | 3/20 | 0.48 |
| ▸ | NOS1 | P29475 | 3/20 | 0.48 |
| ▸ | NOS2 | P35228 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6425871 | 0.87 | IDO1 (0.69) | ALDH1A1IDO1TP53NOS3NOS1 | |
| SCHEMBL10991734 | 0.85 | IDO1 (0.54) | LMNATDP1CYP3A4HPGDHSD17B10 | |
| SCHEMBL17830757 | 0.84 | TDP1 (0.54) | LMNATDP1CYP3A4HPGDHSD17B10 | |
| SCHEMBL10987080 | 0.83 | TDP1 (0.55) | LMNATDP1CYP3A4HPGDHSD17B10 | |
| SCHEMBL16366709 | 0.83 | TMEM97 (0.54) | LMNATDP1CYP3A4HPGDHSD17B10 | |
| SCHEMBL22819341 | 0.83 | P2RX3 (0.54) | LMNATDP1CYP3A4HPGDHSD17B10 | |
| SCHEMBL13367743 | 0.81 | MIF (0.66) | LMNAALDH1A1SMN1; SMN2KMT2APOLB | |
| SCHEMBL1397544 | 0.81 | PTGER4 (0.52) | LMNATDP1CYP3A4HPGDHSD17B10 | |
| SCHEMBL12061417 | 0.80 | NPC1 (0.64) | LMNATDP1CYP3A4HPGDHSD17B10 | |
| SCHEMBL3036188 | 0.80 | ALDH1A1 (0.54) | LMNATDP1CYP3A4HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435831-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |