Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | WNT3A | P56704 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13096505 | 0.87 | SRC (0.55) | NPC1RAB9ASRCMEN1KMT2A | |
| SCHEMBL13096750 | 0.85 | ADAMTS4 (0.56) | NPC1RAB9ASRCMEN1KMT2A | |
| SCHEMBL13096666 | 0.78 | ALDH1A1 (0.52) | SRCMEN1KMT2ACCNA2CDK2 | |
| SCHEMBL5630004 | 0.78 | KMT2A (0.52) | NPC1RAB9ASRCMEN1KMT2A | |
| SCHEMBL2575801 | 0.78 | NPC1 (0.74) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL8393668 | 0.78 | NPC1 (0.73) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL8395990 | 0.78 | NPC1 (0.73) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL254938 | 0.77 | SRC (0.90) | RAB9ASRCMEN1KMT2AALDH1A1 | |
| SCHEMBL8396806 | 0.76 | NPC1 (0.70) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL25894418 | 0.75 | NPC1 (0.74) | NPC1RAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008127727-A1 | BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE | KINEX PHARMACEUTICALS, LLC (US) | 2008-10-23 | — | — | WO | disclosed |