Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.35 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1688165 | 0.79 | PTPN1 (0.69) | PTPN1SMN1; SMN2PTPN2 | |
| SCHEMBL1730640 | 0.79 | PTPN1 (0.69) | PTPN1PTPN2SLC40A1 | |
| SCHEMBL4224258 | 0.79 | PTPN1 (0.69) | PTPN1ALDH1A1KDM4EPTPN2SLC40A1 | |
| SCHEMBL6683753 | 0.79 | PTPN1 (0.69) | PTPN1PTPN2SLC40A1 | |
| SCHEMBL1732116 | 0.79 | PTPN1 (1.00) | PTPN1KDM4EPTPN2SLC40A1 | |
| SCHEMBL1731402 | 0.77 | PTPN1 (0.96) | PTPN1KDM4EPTPN2SLC40A1 | |
| SCHEMBL6689304 | 0.77 | PTPN1 (0.81) | PTPN1ALDH1A1SMN1; SMN2PTPN2MAPK1 | |
| SCHEMBL4231433 | 0.75 | PTPN1 (0.63) | PTPN1ALDH1A1MAPK1 | |
| SCHEMBL15493029 | 0.75 | PTPN1 (0.63) | PTPN1ALDH1A1KDM4ESMN1; SMN2PTPN2 | |
| SCHEMBL1732114 | 0.75 | PTPN1 (0.63) | PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4638444-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE | Bristol-Myers Squibb Company (US) | 2025-10-29 | — | — | EP | disclosed |
| WO-2024137724-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE, COMPOSITIONS, AND METHODS OF USE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-06-27 | — | — | WO | disclosed |
| US-7432292-B2 | Sulfhydantoins as phosphate isosteres | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-10-07 | — | — | US | disclosed |