Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.69 |
| ▸ | PTPN2 | P17706 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4224258 | 0.82 | PTPN1 (0.69) | PTPN1PTPN2MEN1KMT2APOLB | |
| SCHEMBL1730640 | 0.82 | PTPN1 (0.69) | PTPN1PTPN2FAAHMGLLSLC40A1 | |
| SCHEMBL1688165 | 0.82 | PTPN1 (0.69) | PTPN1PTPN2MEN1KMT2AMGLL | |
| SCHEMBL1732116 | 0.81 | PTPN1 (1.00) | PTPN1PTPN2MEN1KMT2ASLC40A1 | |
| SCHEMBL6684475 | 0.80 | PTPN1 (0.66) | PTPN1PTPN2MEN1KMT2AMGLL | |
| SCHEMBL1731402 | 0.80 | PTPN1 (0.96) | PTPN1PTPN2MEN1KMT2ASLC40A1 | |
| SCHEMBL14045280 | 0.79 | PTPN1 (0.65) | PTPN1PTPN2SLC40A1 | |
| SCHEMBL1732114 | 0.78 | PTPN1 (0.63) | PTPN1PTPN2 | |
| SCHEMBL4231433 | 0.78 | PTPN1 (0.63) | PTPN1MEN1KMT2APOLB | |
| SCHEMBL15158587 | 0.78 | PTPN1 (0.63) | PTPN1PTPN2MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004041799-A1 | 5- (SUBSTITUTED PHENYL) -THIADIAZOLIDINE-3-ONES AND THEIR USE AS PTP1B | ASTRAZENECA AB (SE) | 2004-05-21 | — | — | WO | disclosed |