Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.81 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1732116 | 0.90 | PTPN1 (1.00) | PTPN1SLC40A1PTPN2 | |
| SCHEMBL1731402 | 0.88 | PTPN1 (0.96) | PTPN1SLC40A1PTPN2 | |
| SCHEMBL6690418 | 0.86 | PTPN1 (0.73) | PTPN1FAAHMGLLSLC40A1PTPN2 | |
| SCHEMBL6683753 | 0.79 | PTPN1 (0.69) | PTPN1FAAHMGLLSLC40A1MMP13 | |
| SCHEMBL4224258 | 0.79 | PTPN1 (0.69) | PTPN1SLC40A1PTPN2CA12CA9 | |
| SCHEMBL1730640 | 0.79 | PTPN1 (0.69) | PTPN1FAAHMGLLSLC40A1PTPN2 | |
| SCHEMBL1688165 | 0.79 | PTPN1 (0.69) | PTPN1MGLLPTPN2POLBSMN1; SMN2 | |
| SCHEMBL2934032 | 0.78 | PTPN1 (0.70) | PTPN1PTPN2USP2ALDH1A1HPGD | |
| SCHEMBL5129161 | 0.78 | PTPN1 (0.61) | PTPN1SLC40A1PTPN2 | |
| SCHEMBL3918247 | 0.78 | PTPN1 (0.70) | PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004041799-A1 | 5- (SUBSTITUTED PHENYL) -THIADIAZOLIDINE-3-ONES AND THEIR USE AS PTP1B | ASTRAZENECA AB (SE) | 2004-05-21 | — | — | WO | disclosed |