Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.38 |
| ▸ | AR | P10275 | 8/20 | 0.37 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | MPL | P40238 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13360726 | 1.00 | SLC6A4 (0.40) | SLC6A4TRPV3ARRXRAGRIN1 | |
| SCHEMBL13328620 | 0.85 | KIF11 (0.42) | AKR1C3AKR1C2PDE2A | |
| SCHEMBL13328612 | 0.85 | KIF11 (0.42) | AKR1C3AKR1C2PDE2A | |
| SCHEMBL1104680 | 0.84 | SLC6A4 (0.42) | SLC6A4ARRXRAGRIN1GRIN2B | |
| SCHEMBL1720265 | 0.83 | PDE2A (0.50) | SLC6A4TRPV3ARRXRAGRIN1 | |
| SCHEMBL3309320 | 0.81 | RXRA (0.43) | SLC6A4TRPV3ARRXRAGRIN1 | |
| SCHEMBL2399327 | 0.81 | PDE2A (0.43) | SLC6A4ARAKR1C3AKR1C2HDAC8 | |
| SCHEMBL22064887 | 0.81 | SLC6A4 (0.40) | SLC6A4TRPV3ARRXRAGRIN1 | |
| SCHEMBL5019023 | 0.81 | PDE2A (0.43) | SLC6A4ARAKR1C3AKR1C2HDAC8 | |
| SCHEMBL296445 | 0.81 | PDE2A (0.43) | SLC6A4ARAKR1C3AKR1C2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130584-A1 | PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |