Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | HPN | P05981 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14047418 | 0.79 | PTGDR2 (0.42) | SCDHDAC1LMNA | |
| SCHEMBL14047587 | 0.70 | TSHR (0.59) | SCDHDAC1GAARAB9A | |
| SCHEMBL245721 | 0.70 | SCD (0.53) | SCDHDAC1CYP2C9CYP2C19PRMT5 | |
| SCHEMBL1568774 | 0.63 | SCD (0.57) | SCDHDAC1LMNARAB9APOLB | |
| SCHEMBL4267387 | 0.62 | GAA (0.64) | HDAC1GAAKMT2AOPRM1F2 | |
| SCHEMBL20702426 | 0.62 | L3MBTL1 (0.58) | HDAC1CYP2C9CYP2C19PRMT5WDR77 | |
| SCHEMBL244590 | 0.62 | SCD (0.50) | SCDHDAC1LMNARAB9A | |
| SCHEMBL348446 | 0.62 | SCD (0.80) | SCDHDAC1CYP2C9CYP2C19POLB | |
| SCHEMBL30842587 | 0.62 | HDAC1 (0.67) | HDAC1CYP2C19RAB9A | |
| SCHEMBL31011701 | 0.59 | RAB9A (0.54) | HDAC1CYP2C9CYP2C19LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008127349-A2 | HETEROCYCLIC COMPOUNDS SUITABLE FOR THE TREATMENT OF DISEASES RELATED TO ELEVATED LIPID LEVEL | NOVARTIS AG (CH) | 2008-10-23 | — | — | WO | disclosed |