Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 7/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CCND1 | P24385 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PRLHR | P49683 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13249831 | 0.93 | MTHFD2 (0.46) | MTHFD2MAOBCDK4CCND1GRM5 | |
| SCHEMBL13249858 | 0.90 | PRLHR (0.45) | MTHFD2GRM5P2RX7PRLHR | |
| SCHEMBL13249874 | 0.89 | MTHFD2 (0.43) | MTHFD2MAOBCDK4CCND1GRM5 | |
| SCHEMBL13249859 | 0.89 | USP2 (0.49) | MTHFD2CDK4CCND1GRM5PRLHR | |
| SCHEMBL13249851 | 0.88 | GRM5 (0.44) | MTHFD2GRM5PRLHR | |
| SCHEMBL13250445 | 0.88 | P2RX7 (0.45) | MTHFD2P2RX7PRLHR | |
| SCHEMBL13250446 | 0.85 | PRLHR (0.47) | MTHFD2P2RX7PRLHR | |
| SCHEMBL13249840 | 0.85 | MTHFD2 (0.39) | MTHFD2MAOBGRM5P2RX7MTOR | |
| SCHEMBL13249850 | 0.85 | MTHFD2 (0.39) | MTHFD2MAOBGRM5P2RX7MTOR | |
| SCHEMBL13249829 | 0.84 | KMT2A (0.44) | GRM5P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130581-A1 | PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |