⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25183700 | 1.00 | — | — | |
| SCHEMBL10087663 | 0.94 | CYP2D6 (0.41) | — | |
| SCHEMBL21538638 | 0.84 | — | — | |
| SCHEMBL15743624 | 0.84 | — | — | |
| SCHEMBL19648470 | 0.83 | CHRNB4 (0.33) | — | |
| SCHEMBL2917254 | 0.79 | GNAI3 (0.31) | — | |
| SCHEMBL17460677 | 0.79 | CYP2D6 (0.36) | — | |
| SCHEMBL19112768 | 0.79 | SAT1 (0.34) | — | |
| SCHEMBL24017137 | 0.79 | SIGMAR1 (0.55) | — | |
| SCHEMBL13961615 | 0.78 | CYP2D6 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111511730-B | Amide substituted indole compounds useful as TLR inhibitors | 百时美施贵宝公司 | 2023-07-25 | — | — | CN | claimed |
| CN-111511730-A | Amide substituted indole compounds useful as T L R inhibitors | 百时美施贵宝公司 | 2020-08-07 | — | — | CN | claimed |
| CN-111511730-B | Amide substituted indole compounds useful as TLR inhibitors | 百时美施贵宝公司 | 2023-07-25 | — | — | CN | disclosed |
| WO-2023086438-A1 | PRODRUGS OF NEUROSTEROID ANALOGS AND USES THEREOF | EMORY UNIVERSITY (US) | 2023-05-19 | — | — | WO | disclosed |
| WO-2023086438-A1 | PRODRUGS OF NEUROSTEROID ANALOGS AND USES THEREOF | EMORY UNIVERSITY (US) | 2023-05-19 | — | — | WO | disclosed |
| WO-2023086432-A1 | PRODRUGS OF NEUROSTEROID ANALOGS AND USES THEREOF | EMORY UNIVERSITY (US) | 2023-05-19 | — | — | WO | disclosed |
| US-20220002151-A1 | METHOD FOR PRODUCING COMPRESSED HYDROGEN USING ELECTROCHEMICAL SYSTEMS | SAUDI ARABIAN OIL COMPANY (SA) | 2022-01-06 | — | — | US | disclosed |
| CN-111511730-A | Amide substituted indole compounds useful as T L R inhibitors | 百时美施贵宝公司 | 2020-08-07 | — | — | CN | disclosed |
| US-20170226132-A1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-08-10 | — | — | US | disclosed |
| US-20160185780-A1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2016-06-30 | — | — | US | disclosed |
| US-9242976-B2 | Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-01-26 | — | — | US | disclosed |
| CN-1665807-B | Physiologically active substance | MICROBIOPHARM JAPAN CO LTD | 2013-09-11 | — | — | CN | disclosed |
| WO-2013025628-A1 | JANUS KINASE INHIBITOR COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2013-02-21 | — | — | WO | disclosed |
| CN-1351498-B | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO | 2012-08-15 | — | — | CN | disclosed |
| CN-101730693-A | Process for producing macrolide compound and production intermediate thereof | EISAI R&D MAN CO LTD | 2010-06-09 | — | — | CN | disclosed |
| CN-1671856-B | Novel physiologically active substances | EISAI R&D MAN CO LTD | 2010-05-12 | — | — | CN | disclosed |
| CN-101663296-A | 12-membered ring macrolactam derivatives | EISAI R&D MAN CO LTD | 2010-03-03 | — | — | CN | disclosed |
| EP-1632483-B1 | HETEROCYCLIC SUBSTITUTED CARBONYL DERIVATIVES AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | AVENTIS PHARMA INC (US) | 2008-10-29 | — | — | EP | disclosed |
| CN-1671856-A | Novel physiologically active substances | MERCIAN CORP (JP) | 2005-09-21 | — | — | CN | disclosed |
| CN-1665807-A | Novel physiolgically active substances | MERCIAN CORP (JP) | 2005-09-07 | — | — | CN | disclosed |