Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | CTSB | P07858 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CASP6 | P55212 | 2/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7788656 | 0.83 | TDP1 (0.80) | TDP1CTSBALDH1A1ARHPRT1 | |
| SCHEMBL4038529 | 0.80 | TDP1 (0.52) | TDP1CTSBALDH1A1ARHPRT1 | |
| SCHEMBL7117378 | 0.79 | CTSB (0.50) | TDP1CTSBALDH1A1ARHPRT1 | |
| SCHEMBL1275295 | 0.78 | ALDH1A1 (0.47) | TDP1ALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL23715667 | 0.76 | MAPT (0.63) | TDP1CTSBALDH1A1SMN1; SMN2CASP6 | |
| SCHEMBL30184963 | 0.75 | PLAU (0.60) | TDP1ALDH1A1HSD17B10TSHRPLAU | |
| SCHEMBL4365348 | 0.75 | PLAU (0.60) | TDP1ALDH1A1HSD17B10TSHRPLAU | |
| SCHEMBL11206720 | 0.74 | CTSB (0.45) | TDP1CTSBALDH1A1ARHPRT1 | |
| SCHEMBL57166 | 0.74 | TDP1 (1.00) | TDP1CTSBALDH1A1CYP3A4ALOX15 | |
| SCHEMBL29475175 | 0.74 | TDP1 (1.00) | TDP1CTSBALDH1A1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255232-A1 | Naphthyl Derivatives as Inhibitors of Beta-Amyloid Aggregation | APP, BACE1, SNCA | TDP1 526/4885CTSB 482/4885ALDH1A1 1775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.