Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.41 |
| ▸ | RAF1 | P04049 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NQO1 | P15559 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SHBG | P04278 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL961450 | 0.89 | NQO1 (0.47) | KDM4EGAAGLAHSD17B3NPSR1 | |
| SCHEMBL964530 | 0.87 | KDM4E (0.45) | KDM4EGAAGLAHSD17B3NPSR1 | |
| SCHEMBL961165 | 0.87 | TP53 (0.49) | KDM4EGAAGLAHSD17B3NPSR1 | |
| SCHEMBL959705 | 0.84 | HSD17B3 (0.65) | KDM4EGAAGLAHSD17B3NPSR1 | |
| SCHEMBL13391998 | 0.77 | ALDH1A1 (0.54) | KDM4EGAAMAP2K1RAF1ALDH1A1 | |
| SCHEMBL961790 | 0.75 | MAP2K1 (0.60) | KDM4EGAAGLAHSD17B3NPSR1 | |
| SCHEMBL960504 | 0.74 | MAP2K1 (0.65) | KDM4EGAAMAP2K1RAF1ALDH1A1 | |
| SCHEMBL959681 | 0.74 | MAP2K1 (0.73) | KDM4EGAAMAP2K1RAF1ALDH1A1 | |
| SCHEMBL959618 | 0.74 | MAP2K1 (0.53) | KDM4EGAAGLAMAP2K1RAF1 | |
| SCHEMBL963925 | 0.74 | MAP2K1 (0.40) | KDM4EGAAGLAHSD17B3NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1982982-A1 | NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2008-10-22 | — | — | EP | disclosed |