Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4431302 | 0.79 | LMNA (0.52) | LMNAMAPTSMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL3778246 | 0.78 | LMNA (0.71) | LMNAMAPTSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL9612078 | 0.77 | LMNA (0.50) | LMNAMAPTSMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL4431573 | 0.75 | MEN1 (0.57) | LMNAMAPTSMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL16509292 | 0.74 | LMNA (0.45) | LMNAMAPTSMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL20246801 | 0.72 | KMT2A (0.60) | LMNAMAPTALDH1A1TSHRPOLB | |
| SCHEMBL1098208 | 0.72 | LIPG (0.48) | LMNAMAPTSMN1; SMN2NPSR1ALDH1A1 | |
| SCHEMBL9612055 | 0.71 | CA1 (0.52) | ALDH1A1 | |
| SCHEMBL11090677 | 0.71 | NEK2 (0.42) | — | |
| SCHEMBL9400311 | 0.69 | CNR1 (0.43) | LMNAMAPTSMN1; SMN2NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008129080-A1 | 4, 6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES | INGENIUM PHARMACEUTICALS GMBH (DE) | 2008-10-30 | — | — | WO | disclosed |