Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14051060 | 0.91 | ESR1 (0.42) | ESR1ESR2KMT2APPARDPPARA | |
| SCHEMBL14404651 | 0.89 | ESR1 (0.42) | ESR1ESR2KMT2APPARDPPARA | |
| SCHEMBL14032495 | 0.88 | ESR1 (0.51) | ESR1ESR2 | |
| SCHEMBL5101885 | 0.87 | ESR1 (0.57) | ESR1ESR2KMT2A | |
| SCHEMBL14404749 | 0.86 | CYP3A4 (0.43) | ESR1ESR2KMT2APPARDPPARA | |
| SCHEMBL14404649 | 0.85 | SIGMAR1 (0.41) | ESR1ESR2KMT2APPARDPPARA | |
| SCHEMBL14032413 | 0.83 | ESR1 (0.50) | ESR1ESR2KMT2ABCHEACHE | |
| SCHEMBL5109144 | 0.82 | BCHE (0.43) | ESR1ESR2KMT2ADRD2BCHE | |
| SCHEMBL14032436 | 0.82 | ESR1 (0.48) | ESR1ESR2BCHEACHE | |
| SCHEMBL14032216 | 0.82 | ESR1 (0.48) | ESR1ESR2KMT2ABCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435729-B2 | Compounds and methods for modulation of estrogen receptors | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-14 | — | — | US | disclosed |
| US-7279489-B2 | Compounds and methods for modulation of estrogen receptors | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-10-09 | — | — | US | disclosed |