Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.80 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.80 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.80 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.80 |
| ▸ | MEN1 | O00255 | 7/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 11/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TTR | P02766 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1792641 | 0.89 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL22225686 | 0.87 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL22225700 | 0.85 | PIK3CD (0.76) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL15095971 | 0.84 | MEN1 (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL15096000 | 0.84 | MEN1 (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL15095987 | 0.84 | MEN1 (0.76) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL15095962 | 0.84 | MEN1 (0.79) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL15256304 | 0.84 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL1791900 | 0.84 | MEN1 (0.72) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 | |
| SCHEMBL6995384 | 0.83 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140100215-A1 | Methods of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2014-04-10 | — | — | US | disclosed |
| US-8642584-B2 | Method of using PI3K and MEK modulators | EXELIXIS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-8642584-B2 | Method of using PI3K and MEK modulators | EXELIXIS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-20120302545-A1 | Method of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2012-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140100215-A1 | Methods of Using PI3K and MEK Modulators | PIK3CA, PIK3CD, PIK3R1 | PIK3CD 2/4885PIK3CA 1/4885PIK3CB 9/4885 |
| US-20120302545-A1 | Method of Using PI3K and MEK Modulators | PIK3CA, PIK3CD, PIK3R1 | PIK3CD 2/4885PIK3CA 1/4885PIK3CB 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.