Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 11/20 | 0.55 |
| ▸ | MEN1 | O00255 | 10/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15256304 | 0.88 | PIK3CD (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGMAPT | |
| SCHEMBL1791900 | 0.88 | MEN1 (0.72) | PIK3CDPIK3CAPIK3CBPIK3CGMAPT | |
| SCHEMBL12292679 | 0.85 | MAPT (0.62) | PIK3CDPIK3CAPIK3CBPIK3CGMAPT | |
| SCHEMBL14546814 | 0.84 | MAPT (0.66) | PIK3CDPIK3CAPIK3CBPIK3CGMAPT | |
| SCHEMBL14053013 | 0.83 | PIK3CD (0.80) | PIK3CDPIK3CAPIK3CBPIK3CGMAPT | |
| SCHEMBL22225686 | 0.81 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGMAPT | |
| SCHEMBL1792641 | 0.79 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGMAPT | |
| SCHEMBL12292669 | 0.79 | MEN1 (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGMAPT | |
| SCHEMBL22225682 | 0.79 | PIK3CG (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGMAPT | |
| SCHEMBL22225674 | 0.77 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012065057-A2 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS AND METHODS OF THEIR USE | EXELIXIS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |