SCHEMBL1405461

SCHEMBL1405461

CCc1ccc(N=Nc2ccccc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.59
ALDH1A1 P00352 3/20 0.57
MAPT P10636 5/20 0.50
RAB9A P51151 4/20 0.50
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
NPC1 O15118 3/20 0.50
MAPK1 P28482 2/20 0.50
TDP1 Q9NUW8 2/20 0.50
TSHR P16473 1/20 0.50
HSD17B10 Q99714 1/20 0.50
PKM P14618 1/20 0.50
HTT P42858 1/20 0.50
PLAU P00749 1/20 0.48
CASP3 P42574 1/20 0.47
SENP8 Q96LD8 1/20 0.47
SENP7 Q9BQF6 1/20 0.47
SENP6 Q9GZR1 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
TRPA1 O75762 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1405463 1.00 TP53 (0.59) TP53ALDH1A1MAPTRAB9AMEN1
SCHEMBL13638200 0.90 PLAU (0.56) TP53ALDH1A1MAPTRAB9AMEN1
SCHEMBL24212689 0.90 PLAU (0.56) TP53ALDH1A1MAPTRAB9AMEN1
SCHEMBL875358 0.82 ALDH1A1 (0.52) ALDH1A1MAPTRAB9AMEN1KMT2A
SCHEMBL12786219 0.82 ALDH1A1 (0.52) ALDH1A1MAPTRAB9AMEN1KMT2A
SCHEMBL23511155 0.81 PLAU (0.48) TP53MAPTRAB9AMEN1KMT2A
SCHEMBL13278248 0.80 ALDH1A1 (0.63) ALDH1A1MAPTRAB9AMEN1KMT2A
SCHEMBL13278246 0.80 ALDH1A1 (0.63) ALDH1A1MAPTRAB9AMEN1KMT2A
Azobenzene SCHEMBL15261802 0.79 ALDH1A1 (0.71) ALDH1A1MAPTRAB9AMEN1KMT2A
SCHEMBL14850545 0.79 MEN1 (0.54) TP53ALDH1A1MAPTRAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119208436-A Photovoltaic cell preparation method and photovoltaic cell 晶科能源(上饶)有限公司 2024-12-27 CN disclosed
US-9932300-B2 N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2018-04-03 US disclosed
US-20170327743-A1 LIQUID CRYSTAL DISPLAY DEVICE AND METHOD FOR MANUFACTURING SAME JNC CORP (JP) 2017-11-16 US disclosed
US-20160318857-A1 N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2016-11-03 US disclosed
US-9421211-B2 N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2016-08-23 US disclosed
US-8304076-B2 Particles with photochromic and light absorbing material for reimageable medium XEROX CORPORATION (US) 2012-11-06 US disclosed
US-20120115915-A1 N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-05-10 US disclosed
US-7964271-B2 Photochromic medium with erase-on-demand capability XEROX CORPORATION (US) 2011-06-21 US disclosed
EP-1591830-B1 Reimageable medium XEROX CORP (US) 2011-03-09 EP disclosed
US-7709164-B2 Solvent-less process for producing transient documents XEROX CORPORATION (US) 2010-05-04 US disclosed
US-20060222972-A1 Dual-layer protected transient document XEROX CORPORATION 2006-10-05 US disclosed
US-20050287475-A1 Solvent-less process for producing transient documents XEROX CORPORATION 2005-12-29 US disclosed
CN-1702545-A Method for forming temporary image XEROX CORP (US) 2005-11-30 CN disclosed
CN-1702546-A Method for forming temporary image XEROX CORP (US) 2005-11-30 CN disclosed
US-20050244743-A1 Reimageable medium XEROX CORPORATION. 2005-11-03 US disclosed
US-20050244744-A1 Method for forming temporary image XEROX CORPORATION 2005-11-03 US disclosed
US-20050244742-A1 Reimageable medium with light absorbing material XEROX CORPORATION 2005-11-03 US disclosed
EP-1591830-A2 Reimageable medium Xerox Corporation (US) 2005-11-02 EP disclosed
EP-1591831-A2 Reimageable medium with light absorbing material Xerox Corporation (US) 2005-11-02 EP disclosed
EP-1591829-A1 Method for forming temporary image Xerox Corporation (US) 2005-11-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160318857-A1 N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation NSUN2, EIF2AK2, RNGTT TP53 1092/4885ALDH1A1 3464/4885MAPT 1631/4885
US-20120115915-A1 N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION NSUN2, EIF2AK2, RNGTT TP53 1092/4885ALDH1A1 3464/4885MAPT 1631/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.