Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 12/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | GAK | O14976 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.31 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059856 | 0.88 | LRRK2 (0.54) | LRRK2PDE10ASRCPIP4K2ASCN9A | |
| SCHEMBL14059413 | 0.85 | LRRK2 (0.46) | LRRK2PDE10AKMT5A | |
| SCHEMBL14059587 | 0.84 | LRRK2 (0.71) | LRRK2 | |
| SCHEMBL14059179 | 0.84 | LRRK2 (0.53) | LRRK2PDE10AKMT5AKDM4EALDH1A1 | |
| SCHEMBL14059477 | 0.83 | LRRK2 (0.46) | LRRK2KDM4EUSP2ALDH1A1GAA | |
| SCHEMBL14062299 | 0.83 | LRRK2 (0.72) | LRRK2 | |
| SCHEMBL14062301 | 0.83 | LRRK2 (0.72) | LRRK2 | |
| SCHEMBL14059572 | 0.80 | LRRK2 (0.49) | LRRK2PDE10AKMT5A | |
| SCHEMBL14059970 | 0.80 | LRRK2 (0.54) | LRRK2USP2 | |
| SCHEMBL14059210 | 0.78 | LRRK2 (0.48) | LRRK2PDE10AKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | disclosed |