Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.62 |
| ▸ | LCK | P06239 | 5/20 | 0.61 |
| ▸ | BTK | Q06187 | 5/20 | 0.61 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.61 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.61 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.61 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.61 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31371966 | 0.87 | LCK (0.61) | LRRK2LCKBTKMAP2K3MAP2K6 | |
| SCHEMBL14059026 | 0.87 | LCK (0.61) | LRRK2LCKBTKMAP2K3MAP2K6 | |
| SCHEMBL4607280 | 0.83 | LCK (0.44) | LRRK2LCKBTKMAP2K3MAP2K6 | |
| SCHEMBL14059566 | 0.81 | LRRK2 (0.62) | LRRK2LCKBTKMAP2K3MAP2K6 | |
| SCHEMBL14059868 | 0.77 | LRRK2 (1.00) | LRRK2LCKBTKMAP2K3MAP2K6 | |
| SCHEMBL14061350 | 0.76 | BTK (1.00) | LRRK2LCKBTKMAP2K3MAP2K6 | |
| SCHEMBL14059043 | 0.76 | LRRK2 (0.68) | LRRK2 | |
| SCHEMBL15099536 | 0.74 | HSP90AA1 (0.42) | TYMSCDK9DYRK1ADYRK2DYRK1B | |
| SCHEMBL14059201 | 0.73 | LCK (0.41) | LRRK2LCKBTKMAP2K3MAP2K6 | |
| SCHEMBL27586565 | 0.72 | DYRK1A (0.41) | LRRK2LCKBTKMAP2K3MAP2K6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884828-B2 | Substituted cinnolines as inhibitors of LRRK2 kinase activity | IMAGO PHARMACEUTICALS, INC. (US) | 2018-02-06 | — | — | US | disclosed |
| US-20150284337-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2015-10-08 | — | — | US | disclosed |
| CN-103917525-A | Inhibitors of LRRK2 kinase activity | ELAN PHARM INC | 2014-07-09 | — | — | CN | disclosed |
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284337-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | LRRK2, PARK7, PINK1 | LRRK2 1/4885LCK 472/4885BTK 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.