Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.48 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059477 | 0.89 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL14059532 | 0.85 | LRRK2 (0.44) | LRRK2 | |
| SCHEMBL14059769 | 0.83 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL14059154 | 0.83 | LRRK2 (0.49) | LRRK2 | |
| SCHEMBL14062326 | 0.82 | LRRK2 (0.69) | LRRK2SCN9A | |
| SCHEMBL14059131 | 0.81 | LRRK2 (0.70) | LRRK2 | |
| SCHEMBL14059132 | 0.81 | LRRK2 (0.70) | LRRK2 | |
| SCHEMBL14059700 | 0.81 | LRRK2 (0.49) | LRRK2ALOX5APFEN1 | |
| SCHEMBL14059025 | 0.80 | LRRK2 (0.47) | LRRK2 | |
| SCHEMBL14059413 | 0.79 | LRRK2 (0.46) | LRRK2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | disclosed |