Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 6/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1323781 | 0.85 | HTR1A (0.43) | HTR1DHTR1BHTR1ASLC6A4DRD4 | |
| SCHEMBL6528187 | 0.83 | HTR1D (0.43) | HTR1DHTR1BHTR1ASLC6A4 | |
| SCHEMBL1323780 | 0.77 | HTR1D (0.42) | HTR1DHTR1BHTR1ASLC6A4DRD4 | |
| SCHEMBL1406250 | 0.76 | HTR1A (0.46) | HTR1A | |
| SCHEMBL1322969 | 0.75 | HTR1A (0.57) | HTR1DHTR1BHTR1A | |
| SCHEMBL13633559 | 0.75 | ADRA2A (0.48) | HTR1ASLC6A4 | |
| SCHEMBL1322961 | 0.75 | HTR1D (0.55) | HTR1DHTR1BHTR1ASLC6A4HTR2A | |
| SCHEMBL1322976 | 0.73 | HTR1A (0.51) | HTR1DHTR1BHTR1ASLC6A4DRD4 | |
| SCHEMBL1322804 | 0.73 | HTR1D (0.52) | HTR1DHTR1B | |
| SCHEMBL1323806 | 0.73 | HTR1A (0.54) | HTR1DHTR1BHTR1ASLC6A4DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497279-B1 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GMBH (DE) | 2011-03-09 | — | — | EP | claimed |
| EP-1497279-B1 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GMBH (DE) | 2011-03-09 | — | — | EP | disclosed |