Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1322961 | 0.84 | HTR1D (0.55) | HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL1323770 | 0.84 | HRH1 (0.54) | HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL1322969 | 0.81 | HTR1A (0.57) | HTR1AHTR1DHTR1B | |
| SCHEMBL1323787 | 0.79 | HTR1A (0.53) | HTR1ADRD2HTR1DHTR1BSIGMAR1 | |
| SCHEMBL1323812 | 0.79 | HTR1A (0.65) | HTR1A | |
| SCHEMBL1323756 | 0.77 | HTR1A (0.70) | HTR1ADRD2HTR1DHTR1BSIGMAR1 | |
| SCHEMBL1323840 | 0.77 | HTR1A (0.56) | HTR1ADRD2HTR1DHTR1BSIGMAR1 | |
| SCHEMBL1322782 | 0.75 | DRD2 (0.50) | HTR1ADRD2 | |
| SCHEMBL1406042 | 0.74 | HTR1A (0.57) | HTR1ADRD2HTR1DHTR1BSIGMAR1 | |
| SCHEMBL1322834 | 0.74 | HTR1A (0.44) | HTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497279-B1 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GMBH (DE) | 2011-03-09 | — | — | EP | claimed |
| JP-2005523310-A | — | — | 2005-08-04 | — | — | JP | claimed |
| EP-1497279-A2 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GmbH (DE) | 2005-01-19 | — | — | EP | claimed |
| WO-2003087086-A2 | SUBSTITUTED INDOLES | MERCK PATENT GMBH (DE) | 2003-10-23 | — | — | WO | claimed |
| EP-1497279-A2 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GmbH (DE) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003087086-A2 | SUBSTITUTED INDOLES | MERCK PATENT GMBH (DE) | 2003-10-23 | — | — | WO | disclosed |