Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11574200 | 0.89 | GAA (0.56) | GAACA1CA2CA12CA5A | |
| SCHEMBL15623705 | 0.84 | GAA (0.50) | GAACA2ALDH1A1HTTLMNA | |
| SCHEMBL31090146 | 0.84 | GAA (0.77) | GAACA2CYP19A1KDM4EATM | |
| SCHEMBL29634424 | 0.83 | GAA (0.65) | GAACA1CA2CA12CA5A | |
| SCHEMBL8777729 | 0.81 | GAA (0.54) | GAACA1CA2CA12CA5A | |
| SCHEMBL8867396 | 0.81 | GAA (0.67) | GAACA1CA2CA12CA5A | |
| Sulfuric Acid SCHEMBL687450 | 0.81 | GAA (0.57) | GAACA1CA2CA12CA5A | |
| SCHEMBL2207203 | 0.79 | GAA (0.65) | GAACA1CA2CA12CA5A | |
| SCHEMBL15618993 | 0.79 | GAA (0.48) | GAACA1CA2CA12CA5A | |
| SCHEMBL13181092 | 0.79 | GAA (0.69) | GAACYP19A1KDM4EATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513812-B1 | SUBSTITUTED INDOLES | ASTRAZENECA AB (SE) | 2011-03-09 | — | — | EP | disclosed |
| US-7166607-B2 | Substituted indoles | ASTRAZENECA AB (SE) | 2007-01-23 | — | — | US | disclosed |
| US-20050165055-A1 | Novel substituted indoles | ASTRAZENECA AB (SE) | 2005-07-28 | — | — | US | disclosed |
| EP-1513812-A1 | SUBSTITUTED INDOLES | AstraZeneca AB (SE) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003101961-A1 | NOVEL SUBSTITUTED INDOLES | ASTRAZENECA AB (SE) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165055-A1 | Novel substituted indoles | IDO1, IDO2, TPH1 | GAA 3816/4885CA1 3584/4885CA2 1367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.