Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Alendronic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS known ✓ | P14324 | 17/20 | 0.95 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.95 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.70 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alendronic Acid SCHEMBL6856868 | 1.00 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL1115700 | 1.00 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL5974139 | 1.00 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL140619 | 1.00 | FDPS (0.95) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL5973509 | 0.98 | FDPS (0.91) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL1130855 | 0.98 | FDPS (0.91) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL192828 | 0.98 | FDPS (0.91) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL1268399 | 0.98 | FDPS (0.91) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL579003 | 0.98 | FDPS (0.91) | FDPSPDE3ALMNAADRB3PDE4D | |
| Alendronic Acid SCHEMBL7831398 | 0.98 | FDPS (0.91) | FDPSPDE3ALMNAADRB3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1628 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4324492-B1 | MULTIFUNCTIONAL, HYDROGEL HYBRID MATERIAL, METHOD OF ITS PREPARATION AND USE IN THE TREATMENT OF BONE LOSSES | UNIV JAGIELLONSKI (PL) | 2026-03-04 | — | — | EP | claimed |
| US-20250381141-A1 | Formulation of lecithin-modified calcium phosphate nanoparticles with an enhanced cellar uptake as a carrier for bisphosphonates and a method of preparing thereof | POLITECHNIKA WARSZAWSKA (PL) | 2025-12-18 | — | — | US | claimed |
| US-20250375395-A1 | TRANSDERMAL FORMULATION AND DELIVERY METHOD OF LOW SOLUBILITY OR UNSTABLE UNIONIZED NEUTRAL DRUGS BY IN SITU SALT-TO-NEUTRAL DRUG CONVERSION OF SALT DRUG | CORIUM INTERNATIONAL, INC. | 2025-12-11 | — | — | US | claimed |
| WO-2025133965-A2 | RELEASE SYSTEM FOR THE TOPICAL OR INTRA-ARTICULAR ADMINISTRATION OF DRUGS | FIDIA FARMACEUTICI S.P.A. (IT) | 2025-06-26 | — | — | WO | claimed |
| CN-119931931-A | ALPL+ PDGFD +periosteum stem cell, preparation method and application thereof | 北京大学口腔医学院 | 2025-05-06 | — | — | CN | claimed |
| CN-119868587-A | NMN-loaded nanoparticle of stem cell exosome stimulated by alendronate sodium and application thereof | 湖州科元生物科技有限公司 | 2025-04-25 | — | — | CN | claimed |
| CN-119701019-A | Bone metastasis diagnosis and treatment integrated carbon-based nano platform and preparation method and application thereof | 山西省人民医院 | 2025-03-28 | — | — | CN | claimed |
| EP-4204028-B1 | MULTIFUNCTIONAL, HYDROGEL HYBRID MATERIAL, THE METHOD OF ITS PREPARATION AND THE USE IN THE TREATMENT OF BONE LOSSES | UNIV JAGIELLONSKI (PL) | 2024-10-09 | — | — | EP | claimed |
| EP-4426268-A1 | FORMULATION OF LECITHIN-MODIFIED CALCIUM PHOSPHATE NANOPARTICLES WITH AN ENHANCED CELLAR UPTAKE AS A CARRIER FOR BISPHOSPHONATES AND A METHOD OF PREPARING THEREOF | POLITECHNIKA WARSZAWSKA (PL) | 2024-09-11 | — | — | EP | claimed |
| CN-118541142-A | Formulations of lecithin-modified calcium phosphate nanoparticles with enhanced cellular uptake as carriers for bisphosphonates and methods of making the same | 华沙理工大学 | 2024-08-23 | — | — | CN | claimed |
| EP-0690719-A1 | DRY MIX FORMULATION FOR BISPHOSPHONIC ACIDS | MERCK & CO. INC. (US) | 1996-01-10 | — | — | EP | claimed |
| WO-1995029679-A1 | WET GRANULATION FORMULATION FOR BISPHOSPHONIC ACIDS | MERCK & CO., INC. (US) | 1995-11-09 | — | — | WO | claimed |
| EP-0402152-B1 | Crystalline 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid monosodium trihydrate, process therefor and compositions and use thereof | MERCK & CO INC (US) | 1995-11-02 | — | — | EP | claimed |
| EP-0462663-B1 | Improved process for preparing salts of 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid (ABP) | MERCK & CO INC (US) | 1995-09-27 | — | — | EP | claimed |
| US-5358941-A | Treatment of bone disorders, osteoporosis | MERCK & CO., INC. (US) | 1994-10-25 | — | — | US | claimed |
| WO-1994012200-A1 | DRY MIX FORMULATION FOR BISPHOSPHONIC ACIDS | MERCK & CO., INC. (US) | 1994-06-09 | — | — | WO | claimed |
| US-5270365-A | Prevention and treatment of periodontal disease with alendronate | MERCK & CO., INC. (US) | 1993-12-14 | — | — | US | claimed |
| EP-0462663-A1 | Improved process for preparing salts of 4-amino-1-hydroxybutylidene-1, 1-bisphosphonic acid (ABP) | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | claimed |
| US-5019651-A | Reacting 4-Aminobutyric Acid With Phosphorous Acid And Phosphorus Chloride | MERCK & CO., INC. (US) | 1991-05-28 | — | — | US | claimed |
| US-4922007-A | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof | MERCK & CO., INC. (US) | 1990-05-01 | — | — | US | claimed |