Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.47 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.42 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.42 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.42 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.42 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.42 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.42 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL3820155 | 0.98 | CTSS (0.45) | CTSSGPR132ITGA4MAOBPOLB | |
| SCHEMBL234112 | 0.92 | CTSS (0.45) | CTSSGPR132ITGA4MAOBPOLB | |
| Leucine SCHEMBL1406209 | 0.91 | CTSS (0.54) | CTSSITGA4POLBMMEACE | |
| SCHEMBL3194104 | 0.90 | CTSS (0.44) | CTSSGPR132ITGA4MAOBPOLB | |
| Leucine SCHEMBL3816835 | 0.89 | CTSS (0.51) | CTSSITGA4POLBMMEACE | |
| Leucine SCHEMBL1406330 | 0.84 | CTSS (0.62) | CTSSPOLBGAAPSMB11PSMA7 | |
| SCHEMBL231820 | 0.82 | CTSS (0.51) | CTSSITGA4POLBGAAMME | |
| Leucine SCHEMBL3812485 | 0.82 | CTSS (0.59) | CTSSPOLBGAAPSMB11PSMA7 | |
| SCHEMBL2299523 | 0.81 | CTSS (0.50) | CTSSITGA4POLBMMEACE | |
| SCHEMBL1406153 | 0.80 | CTSS (0.50) | CTSSPOLBGAAPSMB11PSMA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355910-B1 | FORMULATION OF BORONIC ACID COMPOUNDS | US OF AMERICA REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES (US) | 2011-03-09 | — | — | EP | claimed |
| EP-0788360-B3 | BORONIC ESTER AND ACID COMPOUNDS, SYNTHESIS AND USES | MILLENNIUM PHARM INC (US) | 2009-08-12 | — | — | EP | claimed |
| EP-1123412-B1 | METHOD FOR MONITORING PROTEASOME INHIBITOR DRUG ACTION | MILLENNIUM PHARM INC (US) | 2004-10-06 | — | — | EP | claimed |