Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 19/20 | 0.53 |
| ▸ | EPAS1 | Q99814 | 19/20 | 0.53 |
| ▸ | EP300 | Q09472 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14071518 | 0.76 | HIF1A (0.76) | HIF1AEPAS1EP300 | |
| SCHEMBL14063559 | 0.75 | HIF1A (0.66) | HIF1AEPAS1EP300 | |
| SCHEMBL2562218 | 0.68 | HIF1A (1.00) | HIF1AEPAS1EP300 | |
| SCHEMBL16509889 | 0.67 | HIF1A (0.74) | HIF1AEPAS1EP300 | |
| SCHEMBL2563961 | 0.65 | HIF1A (1.00) | HIF1AEPAS1EP300 | |
| SCHEMBL13678596 | 0.64 | MAPT (0.67) | — | |
| SCHEMBL14071618 | 0.64 | MAPT (0.63) | — | |
| SCHEMBL7406297 | 0.64 | MAPT (0.59) | — | |
| SCHEMBL2326248 | 0.64 | MAPT (0.64) | — | |
| SCHEMBL2562044 | 0.64 | HIF1A (1.00) | HIF1AEPAS1EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071795-B2 | Hypoxia inducible factor (Hif); for modulating mRNA translation within cells; prevents excessive vascularization | EMORY UNIVERSITY (US) | 2011-12-06 | — | — | US | disclosed |
| US-20080226622-A1 | Hif Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-09-18 | — | — | US | disclosed |
| US-20080226622-A1 | Hif Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-09-18 | — | — | US | disclosed |
| WO-2007025169-A2 | HIF INHIBITORS | EMORY UNIVERSITY (US) | 2007-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080226622-A1 | Hif Inhibitors | HIF1AN, HIF1A, EGLN3 | HIF1A 2/4885EPAS1 12/4885EP300 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.