SCHEMBL14064682

SCHEMBL14064682

C[C@@H](NC(=O)C1CCCCN1C)[C@H](Cc1ccc(Cl)cc1)c1ccc(Cl)cc1

nearest known ligand 0.48

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 15/20 0.48
CNR2 P34972 10/20 0.48
FDFT1 P37268 2/20 0.48
TRPV1 Q8NER1 1/20 0.42
PTGER4 P35408 1/20 0.41
PTGER2 P43116 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4829838 1.00 CNR1 (0.48) CNR1CNR2FDFT1TRPV1PTGER4
Trifluoroacetic Acid SCHEMBL4831463 0.94 CNR1 (0.46) CNR1CNR2FDFT1
SCHEMBL14064688 0.85 CTSK (0.48) CNR1CNR2FDFT1PTGER4PTGER2
SCHEMBL4827977 0.85 CTSK (0.48) CNR1CNR2FDFT1PTGER4PTGER2
SCHEMBL14064696 0.82 PTGER4 (0.50) CNR1CNR2FDFT1PTGER4
SCHEMBL4825437 0.82 PTGER4 (0.50) CNR1CNR2FDFT1PTGER4
SCHEMBL4825617 0.81 CNR1 (0.51) CNR1CNR2FDFT1TRPV1
SCHEMBL14064677 0.81 CNR1 (0.51) CNR1CNR2FDFT1TRPV1
Trifluoroacetic Acid SCHEMBL4829974 0.81 PTGER4 (0.50) CNR1CNR2FDFT1PTGER4
SCHEMBL14064681 0.79 ALDH1A1 (0.54) CNR1CNR2FDFT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7423067-B2 N-(3,4-diphenyl-2-butyl)cyclopentancarboxamide derivatives such as N-(2,3-bis(4-chlorophenyl)-1-methylpropyl)-3-benzoyl-cyclopentane-carboxamide; used for treating conditions including psychological disorders, eating disorders and substance abuse MERCK & CO., INC. (US) 2008-09-09 US disclosed