Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.37 |
| ▸ | DRD3 | P35462 | 4/20 | 0.37 |
| ▸ | HTR7 | P34969 | 9/20 | 0.36 |
| ▸ | HTR1A | P08908 | 9/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4849938 | 0.99 | DRD2 (0.36) | DRD2DRD3HTR7HTR1AADRA1B | |
| Hydrochloric Acid SCHEMBL4857996 | 0.84 | DRD2 (0.39) | DRD2DRD3HTR7HTR1AADRA1B | |
| SCHEMBL14072983 | 0.84 | CHRNA7 (0.44) | DRD2DRD3HTR1AADRA1BSIGMAR1 | |
| SCHEMBL14064798 | 0.83 | DRD2 (0.55) | DRD2DRD3HTR7HTR1AKDM4E | |
| Hydrochloric Acid SCHEMBL4852826 | 0.82 | CHRNA7 (0.43) | DRD2DRD3HTR1AADRA1BSIGMAR1 | |
| Hydrochloric Acid SCHEMBL4856711 | 0.82 | DRD2 (0.54) | DRD2DRD3HTR7HTR1AKDM4E | |
| SCHEMBL4858438 | 0.82 | KDM4E (0.38) | DRD2DRD3HTR7HTR1AADRA1B | |
| Hydrochloric Acid SCHEMBL4859641 | 0.82 | KDM4E (0.41) | DRD2DRD3HTR1AADRA1BKDM4E | |
| SCHEMBL4253554 | 0.82 | HTR7 (0.41) | DRD2HTR7HTR1AADRA1BKDM4E | |
| Hydrochloric Acid SCHEMBL4856411 | 0.81 | KDM4E (0.38) | DRD2DRD3HTR7HTR1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1698620-B1 | BENZENE COMPOUNDS DISUBSTITUTED WITH CYCLIC GROUPS AT THE 1- AND 2-POSITIONS | EISAI R&D MAN CO LTD (JP) | 2016-09-28 | — | — | EP | disclosed |
| US-7425554-B2 | 1,2-di(cyclic)substituted benzene compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-09-16 | — | — | US | disclosed |
| US-7425554-B2 | 1,2-di(cyclic)substituted benzene compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-09-16 | — | — | US | disclosed |
| US-7410971-B2 | 1,2-di(cyclic)substituted benzene compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-08-12 | — | — | US | disclosed |
| US-7410971-B2 | 1,2-di(cyclic)substituted benzene compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-08-12 | — | — | US | disclosed |
| US-20070112002-A1 | 1,2-di(cyclic)substituted benzene compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-05-17 | — | — | US | disclosed |
| US-20070112002-A1 | 1,2-di(cyclic)substituted benzene compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112002-A1 | 1,2-di(cyclic)substituted benzene compounds | CCR10, HRH3, HRH1 | DRD2 554/4885DRD3 315/4885HTR7 1508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.