Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 5/20 | 0.45 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14064857 | 0.85 | IMPDH2 (0.54) | IMPDH2IMPDH1SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL14065171 | 0.84 | IMPDH2 (0.49) | IMPDH2IMPDH1L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL8277282 | 0.84 | IMPDH2 (0.66) | IMPDH2IMPDH1L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL14065211 | 0.75 | IMPDH2 (0.37) | IMPDH2IMPDH1SMN1; SMN2HIF1ARAB9A | |
| SCHEMBL2689376 | 0.73 | IMPDH2 (0.74) | IMPDH2IMPDH1ROCK2 | |
| SCHEMBL14065207 | 0.72 | IMPDH2 (0.46) | IMPDH2IMPDH1L3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL172475 | 0.71 | IMPDH2 (0.55) | IMPDH2IMPDH1LMNARAB9AKMT2A | |
| SCHEMBL6496013 | 0.67 | IMPDH2 (0.74) | IMPDH2IMPDH1 | |
| SCHEMBL2931524 | 0.66 | HSD17B10 (0.57) | RAB9AKMT2AMEN1MAPTROCK2 | |
| SCHEMBL12344525 | 0.65 | IMPDH2 (0.56) | IMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1964561-A1 | Inhibitors of IMPDH enzyme | Vertex Pharmaceuticals Incorporated (US) | 2008-09-03 | — | — | EP | disclosed |