Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 7/20 | 0.55 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.55 |
| ▸ | CDK7 | P50613 | 4/20 | 0.36 |
| ▸ | CCNH | P51946 | 4/20 | 0.36 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.36 |
| ▸ | CTSL | P07711 | 3/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MLNR | O43193 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8277282 | 0.88 | IMPDH2 (0.66) | IMPDH2IMPDH1PTGER1MEN1MAPT | |
| SCHEMBL2735068 | 0.80 | IMPDH2 (0.79) | IMPDH2IMPDH1CDK7CCNHMNAT1 | |
| SCHEMBL12154827 | 0.73 | IMPDH2 (0.83) | IMPDH2IMPDH1 | |
| SCHEMBL14065071 | 0.71 | IMPDH2 (0.45) | IMPDH2IMPDH1MEN1MAPTRAB9A | |
| SCHEMBL2972427 | 0.71 | IMPDH2 (0.55) | IMPDH2IMPDH1CTSLMAPT | |
| SCHEMBL2974342 | 0.71 | IMPDH2 (0.55) | IMPDH2IMPDH1CTSLMAPT | |
| SCHEMBL16411052 | 0.71 | IMPDH2 (0.59) | IMPDH2IMPDH1CTSLPTGER1MAPK1 | |
| Merimepodib SCHEMBL329923 | 0.71 | IMPDH2 (1.00) | IMPDH2IMPDH1 | |
| Merimepodib SCHEMBL329922 | 0.71 | IMPDH2 (1.00) | IMPDH2IMPDH1 | |
| Merimepodib SCHEMBL29376593 | 0.71 | IMPDH2 (1.00) | IMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2494991-A1 | Combination therapy for the treatment of HCV infection | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-05 | — | — | EP | disclosed |
| EP-2142215-B1 | COMBINATION THERAPY FOR THE TREATMENT OF HCV INFECTION | VERTEX PHARMA (US) | 2012-03-07 | — | — | EP | disclosed |
| EP-1917269-B1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMA (US) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366704-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-21 | — | — | EP | disclosed |
| EP-2364984-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-14 | — | — | EP | disclosed |
| EP-2311851-A2 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-04-20 | — | — | EP | disclosed |
| WO-2008106058-A2 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-04 | — | — | WO | disclosed |
| WO-2007025307-A2 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2006039488-A2 | HCV NS3-NS4A PROTEASE INHIBITION | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-04-13 | — | — | WO | disclosed |