Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 4/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | IDH2 | P48735 | 2/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4649728 | 0.78 | THRB (0.47) | THRBCNR2MAPTKDM4EMEN1 | |
| SCHEMBL4649749 | 0.75 | CNR2 (0.73) | THRBCNR2MAPTPOLB | |
| SCHEMBL14381794 | 0.75 | CNR2 (0.56) | THRBCNR2MAPTKDM4EMEN1 | |
| SCHEMBL4648963 | 0.71 | KDM4E (0.46) | THRBCNR2MAPTKDM4EMEN1 | |
| SCHEMBL4648965 | 0.69 | CNR2 (0.48) | THRBCNR2MAPTKDM4EMEN1 | |
| SCHEMBL5080782 | 0.68 | CNR2 (0.77) | CNR2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL4650376 | 0.67 | CNR2 (0.71) | CNR2 | |
| SCHEMBL5212579 | 0.66 | CNR2 (0.77) | CNR2 | |
| SCHEMBL5212362 | 0.66 | CNR2 (0.76) | CNR2 | |
| SCHEMBL2739344 | 0.65 | LMNA (0.64) | THRBMEN1KMT2AAURKAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718613-B1 | PYRIDINE DERIVATIVES AND THEIR USE AS CB2 RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2008-09-03 | — | — | EP | disclosed |