Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR9 | P51686 | 17/20 | 0.55 |
| ▸ | CCR2 | P41597 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13805783 | 0.93 | CCR9 (0.55) | CCR9CCR2LMNAHTTTP53 | |
| SCHEMBL343361 | 0.93 | CCR9 (0.65) | CCR9CCR2LMNAHTTTP53 | |
| SCHEMBL14065202 | 0.90 | LMNA (0.66) | CCR9CCR2LMNAHTTTP53 | |
| SCHEMBL343280 | 0.89 | CCR9 (0.68) | CCR9LMNAHTTTP53MAPT | |
| SCHEMBL10249393 | 0.88 | CCR9 (0.51) | CCR9CCR2LMNAHTTTP53 | |
| SCHEMBL344408 | 0.87 | LMNA (0.52) | CCR9CCR2LMNAHTTTP53 | |
| SCHEMBL344537 | 0.85 | CCR9 (0.63) | CCR9CCR2LMNAHTTTP53 | |
| SCHEMBL10249410 | 0.84 | CCR9 (0.69) | CCR9LMNAHTTTP53MAPT | |
| SCHEMBL342947 | 0.83 | CCR9 (0.69) | CCR9LMNAHTTTP53MAPT | |
| SCHEMBL13805667 | 0.83 | CCR9 (0.58) | CCR9LMNAHTTTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7420055-B2 | Antagonists of the chemokine receptor 9 (CCR9); inhibit TECK ligand; antiinflammatory agents and immunoregulators; inflammatory bowel disease; (2-phenylsulfonamidophenyl)-pyridinyl-methanones; N-[4-chloro-2(pyridine4-carbonyl)-phenyl]4-morpholin-4-yl-benzenesulfonamide | CHEMOCENTRYX, INC. (US) | 2008-09-02 | — | — | US | disclosed |