Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 11/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.53 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16204637 | 0.87 | CSNK1D (0.45) | SCN10AKCNH2CSNK1DCSNK1G2CSNK1A1 | |
| SCHEMBL12755406 | 0.83 | SCN10A (0.54) | SCN10AKCNH2CSNK1DCSNK1G2CSNK1A1 | |
| SCHEMBL18233050 | 0.80 | CSNK1D (0.64) | SCN10AKCNH2CSNK1DCSNK1G2CSNK1A1 | |
| SCHEMBL12829207 | 0.80 | SCN10A (0.51) | SCN10AKCNH2CSNK1DCSNK1G2CSNK1A1 | |
| SCHEMBL19779070 | 0.80 | SCN10A (0.58) | SCN10AKCNH2CSNK1DCSNK1G2CSNK1A1 | |
| SCHEMBL239188 | 0.80 | LMNA (0.60) | SCN10AKCNH2CSNK1DCSNK1G2CSNK1A1 | |
| SCHEMBL14065420 | 0.78 | LMNA (0.60) | KCNH2ABL1KDR | |
| SCHEMBL805057 | 0.77 | GAA (0.68) | SCN10AKCNH2CSNK1DCSNK1G2CSNK1A1 | |
| SCHEMBL846652 | 0.77 | SCN10A (0.78) | SCN10AKCNH2CSNK1DCSNK1G2CSNK1A1 | |
| SCHEMBL21769332 | 0.77 | CSNK1D (0.48) | CSNK1DCSNK1G2CSNK1A1GSK3BFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7419967-B2 | Sulfonamide inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-02 | — | — | US | disclosed |
| US-7419967-B2 | Sulfonamide inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-02 | — | — | US | disclosed |