Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.46 |
| ▸ | SLC18A2 | Q05940 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14065598 | 1.00 | MAPT (0.54) | MAPTPKMCHRM2CHRM4CHRM5 | |
| SCHEMBL14376312 | 1.00 | MAPT (0.54) | MAPTPKMCHRM2CHRM4CHRM5 | |
| SCHEMBL13473844 | 0.91 | SLC6A3 (0.53) | MAPTPKMCHRM2CHRM4CHRM5 | |
| SCHEMBL14376322 | 0.91 | SLC6A3 (0.53) | MAPTPKMCHRM2CHRM4CHRM5 | |
| SCHEMBL13473847 | 0.91 | SLC6A3 (0.53) | MAPTPKMCHRM2CHRM4CHRM5 | |
| SCHEMBL12592383 | 0.91 | SLC6A3 (0.53) | MAPTPKMCHRM2CHRM4CHRM5 | |
| SCHEMBL14065597 | 0.83 | SLC6A2 (0.43) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL14065595 | 0.83 | SLC6A2 (0.43) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL4094243 | 0.83 | SLC6A3 (0.59) | MAPTPKMSLC6A3SLC18A2SLC6A2 | |
| SCHEMBL12701406 | 0.78 | MAPT (0.38) | MAPTALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7419990-B2 | Piperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-7329673-B2 | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |