Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL497599 | 0.81 | CA12 (0.33) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL498168 | 0.81 | CHRM1 (0.36) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL498290 | 0.78 | CA1 (0.38) | ALDH1A1 | |
| SCHEMBL5209480 | 0.74 | ALDH1A1 (0.46) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL13359384 | 0.73 | — | — | |
| SCHEMBL14065631 | 0.73 | KDM4E (0.39) | MAPTPAOXLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL12015835 | 0.72 | CHRM1 (0.43) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| Acetic Acid SCHEMBL11511846 | 0.70 | FFAR3 (0.44) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| Acetic Acid SCHEMBL7704581 | 0.70 | FFAR3 (0.44) | CHRM2CHRM4CHRM1CHRM3CHRM5 | |
| SCHEMBL4536281 | 0.69 | KDM4E (0.31) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7419990-B2 | Piperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-7419990-B2 | Piperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-09-02 | — | — | US | disclosed |