Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.31 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.31 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14066557 | 0.93 | TP53 (0.37) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL14066641 | 0.91 | TP53 (0.52) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL14066689 | 0.89 | MEN1 (0.46) | S1PR1MEN1KMT2ARENGABRA1 | |
| SCHEMBL14066661 | 0.89 | TP53 (0.52) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL4651628 | 0.86 | GABRA1 (0.52) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL14066629 | 0.86 | BCL2L1 (0.56) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL4651543 | 0.84 | BCL2L1 (0.46) | TP53MDM2BCL2L1MCL1MEN1 | |
| SCHEMBL14066551 | 0.82 | TP53 (0.37) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL4653801 | 0.81 | GABRA1 (0.43) | TP53MDM2BCL2L1MCL1S1PR1 | |
| SCHEMBL14066642 | 0.80 | TP53 (0.53) | TP53MDM2BCL2L1MCL1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408986-B1 | PROTEOMIMETIC COMPOUNDS AND METHODS | UNIV YALE (US) | 2008-09-24 | — | — | EP | disclosed |